Analytical Sciences
XenoTech’s Analytical Sciences department specializes in high quality support for all the analytical needs of our contract services groups. Department personnel have a high level of expertise, pharmaceutical company experience and knowledge of FDA Bioanalytical Guidelines. The group's focus is on applying our LC/MS technology to maximize both the quality and throughput of the data we generate to ensure that your project needs are met.
Featured instruments and services include:
- Multiple PE Sciex API2000, API3000 and API4000 LC/MS/MS systems
- Shimadzu Sil-HT autosamplers minimize carryover and maximize throughput
- Shimadzu HPLC pumping systems
- AIM Research LC-ARC detector provides enhanced sensitivity of radioactive compounds
- Metabolite assays validated according to FDA Bioanalytical Guidelines (PDF)
- Validated analytical methods - human liver microsomes
CYP |
Substrate |
Metabolite Monitored |
CYP1A2 |
Phenacetin |
Acetaminophen |
CYP2A6 |
Coumarin |
7-Hydroxycoumarin |
CYP2B6 |
Bupropion |
Hydroxybupropion |
CYP2B6 |
Efavirenz |
8-Hydroxyefavirenz |
CYP2C8 |
Paclitaxel |
6α-Hydroxypaclitaxel |
CYP2C8 |
Amodiaquine |
N-Desethylamodiaquine |
CYP2C9 |
Diclofenac |
4´-Hydroxydiclofenac |
CYP2C19 |
S-Mephenytoin |
4´-Hydroxymephenytoin |
CYP2D6 |
Dextromethorphan |
Dextrorphan |
CYP2D6 |
Bufuralol |
1´-Hydroxybufuralol |
CYP2E1 |
Chlorzoxazone |
6-Hydroxychlorzoxazone |
CYP3A4/5 |
Testosterone |
6β-Hydroxytestosterone |
CYP3A4/5 |
Midazolam |
1´-Hydroxymidazolam |
CYP3A4/5 |
Nifedipine |
Dehydronifedipine |
CYP3A4/5 |
Atorvastatin |
o-Hydroxyatorvastatin |
CYP4A11 |
Lauric acid |
12-Hydroxylauric acid |
UGT1A1 |
Estradiol |
Estradiol-3-Glucuronide |
UGT1A4 |
Trifluoperazine |
Trifluoperazine Glucuronide |
UGT1A6 |
Naphthol |
1-Naphthol Glucuronide |
UGT1A6 |
4-Methylumbelliferone |
4-Methylumbelliferone-β-D-Glucuronide |
UGT1A9 |
Propofol |
Propofol Glucuronide |
UGT2B7 |
Morphine |
Morphine 3-β-D-Glucuronide |
UGT2B8 |
4-Methylumbelliferone |
4-Methylumbelliferone-β-D-Glucuronide |
NAT1 |
5-Aminosalicylic acid |
5-Acetamido-salicylic acid |
MAO-A |
5-Hydroxytryptamine |
5-Hydroxytryptophol |
MAO-B |
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