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Human Hepatocyte Characterization Table Click on the link below to view characterization data from XenoTech's available lots of cryopreserved hepatocytes. Click here to download file.
ISSX 2006, Poster 107 Kinetic Constants and Sample-to-Sample Variation in the Rate of Metabolism of Two or More Substrates for Human Liver Microsomal CYP1A2, CYP2B6, CYP2C8, CYP2C9, and CYP3A4 Marker substrates for certain CYPs have changed for several reasons, including the need for improved selectivity and sensitivity, reliable substrates for LC/MS/MS analysis, and substrates that provide greater repeatability. The objectives of this study were to compare sample-to-sample variation in cytochrome P450 enzymatic rates between two or more CYP-specific substrates and to determine Michaelis-Menten kinetic constants (Km and Vmax) for these same reactions using a pool of human liver microsomes. Click here to download file.
ISSX 2006, Poster 95 The Effects of Gender, Age and Ethnicity on Human Cytochrome P450 Activity The expression of CYP enzymes is influenced by both endogenous and exogenous factors. The aim of this analysis was to evaluate whether the age, gender, or ethnicity of the donor should influence the selection of human liver microsomes for drug metabolism studies, as well as whether cigarette smoking and alcohol consumption are reliable indicators of elevated CYP1A2 and CYP2E1 activity, respectively. Click here to download file.
Viable yield versus enzymatic activity Cryopreserved human hepatocytes: viable cell yield should not be used as a predictor of drug metabolizing enzyme activites It has long been understood that samples of cryopreserved human hepatocytes can vary in the number of viable cells obtained post-thaw. The focus of this study was to determine if the viable cell yield of cryopreserved human hepatocytes could be used as a predictor of enzymatic competency. Click here to download file.

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