IC50
Concentration of inhibitor at which 50% of the turnover of a single concentration of a form-selective substrate is inhibited.
IgG
Immunoglobulin G; one of the major classes of antibodies. (The others are IgA, IgE and IgM). IgG is the major antibody produced after prolonged or repetitive exposure of an animal to an antigen (or immunogen).
immunogen
See
Antigen.
in vitro
A biological process made to occur in a laboratory vessel or other controlled experimental environment rather than within a living organism or natural setting.
in vivo
Literally, “in life.” An experiment conducted with a living organism (such as a laboratory animal).
inducer
A compound that increases (up-regulates) the levels of cytochrome P450 and/or other drug-metabolizing enzymes.
induction
The process whereby a chemical increases (up regulates) the levels of cytochrome P450 and/or other drug-metabolizing enzymes.
inhibition
A decrease in enzyme activity. Note: a decrease in actual enzyme levels is called suppression.
inhibitor
A compound that decreases the activity of an enzyme.