Inhibitory Antibodies
Our antibodies for use in
inhibition studies are featured in this section along with information regarding inhibition rates and recommended usage procedures.
Included are XenoTech's purified
monoclonal antibodies. This purification step minimizes or eliminates artifacts caused by non-specific binding to albumin and other proteins that are present in large amounts in ascites fluid and serum. These artifacts can confound attempts to interpret the results obtained in
Reaction Phenotyping (“enzyme mapping”) studies; thus, the use of purified inhibitory monoclonal antibodies simplifies, streamlines, and reduces the cost of such studies.
PRODUCTS
Target |
Product No. |
Description |
Inhibition observed |
Other CYPs inhibited (>20%) |
Volume per test |
Volume per vial |
CYP1A1 |
PI1A1* |
Polyclonal against E. coli expressed Human 1A1 |
>80%1 |
CYP2C8 (<80%) |
5 mL |
100 mL |
CYP1A1/2 |
PI1A1-2* |
Polyclonal against E. coli expressed Human 1A1/2 |
>80%1 |
CYP2E1 (<50%) |
5 mL |
100 mL |
CYP1A1 |
MA1A1 |
Ascites fluid, monoclonal raised in mouse against Baculovirus expressed 1A1 |
>80% |
None |
10 mL |
500 mL |
CYP1A2 |
MP1A2 |
Purified monoclonal raised in mouse against Baculovirus expressed 1A2 |
>80%2 |
None |
50 mL |
520 mL |
CYP1A2 |
MA1A2 |
Ascites fluid, monoclonal raised in mouse against Baculovirus expressed 1A2 |
>80%2 |
None |
1 mL |
500 mL |
CYP1A2 |
PIWB1A2* |
Polyclonal against E. coli expressed Human 1A2 |
>80%1 |
CYP1A1 (<25%) |
5 mL |
100 mL |
CYP2A6 |
MP2A6 |
Purified monoclonal raised in mouse against Baculovirus expressed 2A6 |
>90% |
None |
50 mL |
520 mL |
CYP2A6 |
MA2A6 |
Ascites fluid, monoclonal raised in mouse against Baculovirus expressed 2A6 |
>90% |
None |
2 mL |
500 mL |
CYP2A6 |
PI2A6* |
Polyclonal against E. coli expressed Human 2A6 |
>90% |
None |
2 mL |
100 mL |
CYP2B6 |
A3021 |
Polyclonal against Human 2B6 (Antigen is Rat 2B1) |
>75% |
CYP2A6 (<60%) |
10 mL |
500 mL |
CYP2B6 |
MP2B6 |
Purified monoclonal raised in mouse against Baculovirus expressed 2B6 |
>80% |
None |
50 mL |
520 mL |
CYP2B6 |
MA2B6 |
Ascites fluid, monoclonal raised in mouse against Baculovirus expressed 2B6 |
>80% |
None |
5 mL |
500 mL |
CYP2C8 |
MP2C8 |
Purified monoclonal raised in mouse against Baculovirus expressed 2C8 |
>90% |
None |
50 mL |
520 mL |
CYP2C8 |
MA2C8 |
Ascites fluid, monoclonal raised in mouse against Baculovirus expressed 2C8 |
>90% |
None |
2 mL |
500 mL |
CYP2C8 |
PI2C8* |
Polyclonal against E. coli expressed Human 2C8 |
>95% |
None |
2 mL |
100 mL |
CYP2C9 |
MP2C9 |
Purified monoclonal raised in mouse against Baculovirus expressed 2C9 |
>85% |
None |
50 mL |
520 mL |
CYP2C9 |
MA2C9 |
Ascites fluid, monoclonal raised in mouse against Baculovirus expressed 2C9 |
>85% |
None |
5 mL |
500 mL |
CYP2C9 |
PI2C9* |
Polyclonal against E. coli expressed Human 2C9 |
>80% |
CYP2C8 (<40%) CYP2C19 (<35%) |
10 mL |