Beagle Dog Liver Subcellular Fractions
View Products XenoTech offers pooled liver microsomes, S9 fractions and cytosol from sexually-mature male and female Beagle dogs.
DESCRIPTION
PACKAGING
CHARACTERIZATION PROVIDED
PRODUCTS
DESCRIPTION
Liver microsomes contain cytochromes P450, flavin-monooxygenases, carboxylesterases, epoxide hydrolase, UDP-glucuronosyltransferases and other drug-metabolizing enzymes, and are intended for use in
in vitro studies of xenobiotic metabolism.
The
S9 fraction is a mixture of microsomes and cytosol. Accordingly, it contains a wide variety of Phase 1 and Phase 2 enzymes including P450 enzymes, flavin-monooxygenases, carboxylesterases, epoxide hydrolase, UDP-glucuronosyltransferases, sulfotransferases, methyltransferases, acetyltransferases, glutathione
S‑transferases and other drug-metabolizing enzymes.
Liver cytosol contains many xenobiotic metabolizing enzymes including carboxylesterases, soluble epoxide hydrolases, alcohol dehydrogenases, aldehydes oxidases, xanthine oxidases, diamine oxidases, sulfotransferases, glutathione
S‑transferases, etc.
Return to topPACKAGING
MicrosomesConcentration: 20 mg/mL
Suspension buffer: 250 mM sucrose
S9 fractionConcentration: 20 mg/mL
Suspension buffer: 50 mM TRIS
·HCl (pH 7.4 at 4°C) containing 150 mM KCl and 2 mM EDTA
CytosolConcentration: 10 mg/mL
Suspension buffer: 50 mM TRIS
·HCl (pH 7.4 at 4°C) containing 150 mM KCl and 2 mM EDTA.
Return to topCHARACTERIZATION PROVIDED
The following lot-specific product information is included with each order of non-human liver microsomes.
- Specific content of cytochrome P450
- Specific content of cytochrome b5
- NADPH-cytochrome c reductase activity
- 7-Ethoxycoumarin O-dealkylation
- Animal Information and Husbandry
Return to topPRODUCTS
Product No. |
Product |
Gender |
Amount |
D1000 |
Pooled Beagle Dog Liver Microsomes |
Male |
0.5 mL at 20 mg/mL |
D1000.S9 |
Pooled Beagle Dog Liver S9 Fraction |
Male |
1.0 mL at 20 mg/mL |
D1000.C |
Pooled Beagle Dog Liver Cytosol |
Male |
1.0 mL at 10 mg/mL |
D1500 |
Pooled Beagle Dog Liver Microsomes |
Female |
0.5 mL at 20 mg/mL |
D1500.S9 |
Pooled Beagle Dog Liver S9 Fraction |
Female |
1.0 mL at 20 mg/mL |
D1500.C |
Pooled Beagle Dog Liver Cytosol |
Female |
1.0 mL at 10 mg/mL |
Return to TopOrder Fax: 913.227.7171
Order E-mail: info@xenotechllc.com
Call 877.588.7530 (toll-free US and Canada) for pricing and availability.
If ordering outside of North America, please see our Distributor information.