Hartley Albino Guinea Pig Subcellular Fractions
View Products XenoTech offers pooled liver microsomes, S9 fractions and cytosol from sexually-mature male Hartley Albino guinea pigs.
DESCRIPTION
PACKAGING
CHARACTERIZATION PROVIDED
PRODUCT DETAILS
PRODUCTS
DESCRIPTION
Liver microsomes contain cytochromes P450, flavin-monooxygenases, carboxylesterases, epoxide hydrolase, UDP-glucuronosyltransferases and other drug-metabolizing enzymes, and are intended for use in
in vitro studies of xenobiotic metabolism.
The S9 fraction is a mixture of microsomes and cytosol. Accordingly, it contains a wide variety of Phase 1 and Phase 2 enzymes including P450 enzymes, flavin-monooxygenases, carboxylesterases, epoxide hydrolase, UDP-glucuronosyltransferases, sulfotransferases, methyltransferases, acetyltransferases, glutathione S‑transferases and other drug-metabolizing enzymes.
Liver cytosol contains many xenobiotic metabolizing enzymes including carboxylesterases, soluble epoxide hydrolases, alcohol dehydrogenases, aldehydes oxidases, xanthine oxidases, diamine oxidases, sulfotransferases, glutathione S‑transferases, etc.
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Microsomes
Concentration: 20 mg/mL
Suspension buffer: 250 mM sucrose
S9 fraction
Concentration: 20 mg/mL
Suspension buffer: 50 mM TRIS·HCl (pH 7.4 at 4°C) containing 150 mM KCl and 2 mM EDTA
Cytosol
Concentration: 10 mg/mL
Suspension buffer: 50 mM TRIS·HCl (pH 7.4 at 4°C) containing 150 mM KCl and 2 mM EDTA
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CHARACTERIZATION PROVIDED
The following lot-specific product information is included with each order of non-human liver microsomes.
- Specific content of cytochrome P450
- Specific content of cytochrome b5
- NADPH-cytochrome c reductase activity
- 7-Ethoxycoumarin O-dealkylation
- Animal Information and Husbandry
Return to TopPRODUCT DETAILS
NOMENCLATURE Crl:(HA)BR ORIGIN To CRL in 1968 from Medical Research Council, Millhill, England. Caesarean rederived in 1969. COAT COLOR Albino.
Return to TopPRODUCTS
Product No. |
Product |
Gender |
Amount |
G1000 |
Pooled Hartley Albino Guinea Pig Liver Microsomes |
Male |
0.5 mL at 20 mg/mL |
G1000.S9 |
Pooled Hartley Albino Guinea Pig Liver S9 Fraction |
Male |
1.0 mL at 20 mg/mL |
G1000.C |
Pooled Hartley Albino Guinea Pig Liver Cytosol |
Male |
1.0 mL at 10 mg/mL |
Return to TopOrder Fax: 913.227.7171
Order E-mail: info@xenotechllc.com
Call 877.588.7530 (toll-free US and Canada) for pricing and availability.
If ordering outside of North America, please see our Distributor information.