CD-1 Mouse Subcellular Fractions
View Products XenoTech offers pooled liver
microsomes,
S9 fractions and
cytosol from sexually-mature male and female CD-1 mice.
DESCRIPTIONPACKAGINGCHARACTERIZATION PROVIDEDPRODUCT DETAILSPRODUCTSDESCRIPTION
Liver microsomes contain cytochromes P450, flavin-monooxygenases, carboxylesterases, epoxide hydrolase, UDP-glucuronosyltransferases and other drug-metabolizing enzymes, and are intended for use in
in vitro studies of xenobiotic metabolism.
The
S9 fraction is a mixture of microsomes and cytosol. Accordingly, it contains a wide variety of Phase 1 and Phase 2 enzymes including P450 enzymes, flavin-monooxygenases, carboxylesterases, epoxide hydrolase, UDP-glucuronosyltransferases, sulfotransferases, methyltransferases, acetyltransferases, glutathione
S‑transferases and other drug-metabolizing enzymes.
Liver cytosol contains many xenobiotic metabolizing enzymes including carboxylesterases, soluble epoxide hydrolases, alcohol dehydrogenases, aldehydes oxidases, xanthine oxidases, diamine oxidases, sulfotransferases, glutathione
S‑transferases, etc.
Return to topPACKAGING
MicrosomesConcentration: 20 mg/mL
Suspension buffer: 250 mM sucrose
S9 fractionConcentration: 20 mg/mL
Suspension buffer: 50 mM TRIS
·HCl (pH 7.4 at 4°C) containing 150 mM KCl and 2 mM EDTA
CytosolConcentration: 10 mg/mL
Suspension buffer: 50 mM TRIS
·HCl (pH 7.4 at 4°C) containing 150 mM KCl and 2 mM EDTA
Return to topCHARACTERIZATION PROVIDED
The following lot-specific product information is included with each order of non-human liver microsomes.
- Specific content of cytochrome P450
- Specific content of cytochrome b5
- NADPH-cytochrome c reductase activity
- 7-Ethoxycoumarin O-dealkylation
- Animal Information and Husbandry
Return to topPRODUCT DETAILS
NOMENCLATURE Crl:CD-1® (ICR) BR
ORIGIN The original group of Swiss mice that served as progenitors of this stock consisted of two male and seven female albino mice derived from a non-inbred stock in the laboratory of Dr. de Coulon, Centre Anticancereux Romand, Lausanne, Switzerland. These animals were imported into the United States by Dr. Clara Lynch of the Rockefeller Institute in 1926. The Hauschka Ha/ICR stock was initiated in 1948 at the Institute for Cancer Research in Philadelphia from "Swiss" mice of Rockefeller origin. To Dr. Edward Mirand of Roswell Park Memorial Institute where they were designated as HaM/ICR. To CRL in 1959 and caesarean rederived that same year.
COAT COLOR Albino.
Return to topPRODUCTS
Product No. |
Product |
Gender |
Amount |
M1000 |
Pooled CD-1 Mouse Liver Microsomes |
Male |
0.5 mL at 20 mg/mL |
M1000.S9 |
Pooled CD-1 Mouse Liver S9 Fraction |
Male |
1.0 mL at 20 mg/mL |
M1000.C |
Pooled CD-1 Mouse Liver Cytosol |
Male |
1.0 mL at 10 mg/mL |
M1500 |
Pooled CD-1 Mouse Liver Microsomes |
Female |
0.5 mL at 20 mg/mL |
M1500.S9 |
Pooled CD-1 Mouse Liver S9 Fraction |
Female |
1.0 mL at 20 mg/mL |
M1500.C |
Pooled CD-1 Mouse Liver Cytosol |
Female |
1.0 mL at 10 mg/mL |
Return to TopOrder Fax: 913.227.7171
Order E-mail: info@xenotechllc.com
Call 877.588.7530 (toll-free US and Canada) for pricing and availability.
If ordering outside of North America, please see our Distributor information.