Cynomolgus Monkey Liver Subcellular Fractions
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PRODUCTSDESCRIPTION
XenoTech offers pooled liver microsomes, S9 fractions and cytosol from sexually-mature male and female Cynomolgus monkeys.
Liver microsomes contain cytochromes P450, flavin-monooxygenases, carboxylesterases, epoxide hydrolase, UDP-glucuronosyltransferases and other drug-metabolizing enzymes and are intended for in vitro studies of xenobiotic metabolism.
The S9 fraction is a mixture of microsomes and cytosol. Accordingly, it contains a wide variety of phase I and phase II enzymes including P450 enzymes, flavin-monooxygenases, carboxylesterases, epoxide hydrolase, UDP-glucuronosyltransferases, sulfotransferases, methyltransferases, acetyltransferases, glutathione S‑transferases and other drug-metabolizing enzymes.
Liver cytosol contains many xenobiotic metabolizing enzymes including carboxylesterases, soluble epoxide hydrolases, alcohol dehydrogenases, aldehydes oxidases, xanthine oxidases, diamine oxidases, sulfotransferases, glutathione S‑transferases, etc.
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MicrosomesConcentration: 20 mg/mL
Suspension buffer: 250 mM sucrose
S9 fractionConcentration: 20 mg/mL
Suspension buffer: 50 mM TRIS
·HCl (pH 7.4 at 4°C) containing 150 mM KCl and 2 mM EDTA
CytosolConcentration: 10 mg/mL
Suspension buffer: 50 mM TRIS
·HCl (pH 7.4 at 4°C) containing 150 mM KCl and 2 mM EDTA
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Specific content of cytochrome P450 Specific content of cytochrome b5 NADPH-cytochrome c reductase activity 7-Ethoxyresorufin O-dealkylation Animal information and husbandry
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SAFETY, HANDLING AND STORAGE
Policy statement concerning the safety of non-human primate-derived material
XenoTech manufactures products derived from non-human primate tissue for the purpose of xenobiotic research.
All tissue used to manufacture these products is obtained from reliable sources within the
United States, and is obtained from disease-free (asymptomatic) animals under the care of a veterinarian.
In accordance with federal (USDA) regulations, all non-human primates entering the
United States are placed in quarantine for a period of thirty days.
If an animal is infected with Ebola virus, it would die during the quarantine period, and hence, would not reside in a primate colony in the
United States.
For this reason, Ebola virus testing is not a common procedure in the
United States.
Animals are tested for Simian Herpes B virus (SBV), Simian Retrovirus (SRV), and Simian Immunodeficiency virus (SIV).
All non-human primate tissue utilized at XenoTech is obtained from animals which have tested seronegative for these viruses.Although animals are quarantined and tested for certain infectious diseases, it is not scientifically possible to guarantee that non-human primate-derived material is free of
all infectious agents and poses absolutely no health risk.
Therefore, we strongly caution all researchers who use non-human primate-derived material to treat such material as a potential biohazard, and to observe all national, regional, and local regulations governing the handling of such material.
Even if non-human primate-derived material has been tested for the presence of specific infectious agents by highly sensitive techniques, such as PT-PCR, and found to test negative, the material should still be treated as a potential biohazard.
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PRODUCTS
Product No. |
Product |
Gender |
Amount |
P2000 |
Pooled Cynomolgus Monkey Liver Microsomes |
Male |
0.5 mL at 20 mg/mL |
P2000.S9 |
Pooled Cynomolgus Monkey Liver S9 Fraction |
Male |
1.0 mL at 20 mg/mL |
P2000.C |
Pooled Cynomolgus Monkey Liver Cytosol |
Male |
1.0 mL at 10 mg/mL |
P2500 |
Pooled Cynomolgus Monkey Liver Microsomes |
Female |
0.5 mL at 20 mg/mL |
P2500.S9 |
Pooled Cynomolgus Monkey Liver S9 Fraction |
Female |
1.0 mL at 20 mg/mL |
P2500.C |
Pooled Cynomolgus Monkey Liver Cytosol |
Female |
1.0 mL at 10 mg/mL |
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Order E-mail: info@xenotechllc.com
Call 877.588.7530 (toll-free US and Canada) for pricing and availability.
If ordering outside of North America, please see our Distributor information.