IGS Sprague-Dawley Rat Lung Subcellular Fractions
View ProductsDESCRIPTIONPACKAGINGCHARACTERIZATION PROVIDEDPRODUCT DETAILSRELATED PRODUCTSPRODUCTSDESCRIPTION
As the primary site for the entrance of airborne agents, and as the recipient of all cardiac output, the lungs may provide both first-pass and systemic metabolism of xenobiotics through several enzymatic pathways including both cytochrome P450 and Phase 2 enzymes.
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Microsomes
Concentration: 10 mg/mL
Suspension buffer: 250 mM sucrose
S9 fraction
Concentration: 5 mg/mL
Suspension buffer: 50 mM TRIS·HCl (pH 7.4 at 4°C) containing 150 mM KCl and 2 mM EDTA
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CHARACTERIZATION PROVIDED
XenoTech’s lung subcellular fractions are characterized for the following activities:
- NADPH-cytochrome c reductase
- 7-Ethoxyresorufin O-dealkylation
- 4-Methylumbelliferone glucuronidation
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NOMENCLATURE Crl:CD (SD)IGS BR ORIGIN Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. To CRL in 1950 from Sprague Dawley, Inc. Caesarean rederived in 1955 from original Charles River Sprague Dawley® colonies. In 1991, 8 colonies were selected to form the IGS Foundation Colony. Rederived into isolator foundation colony in 1997. IGS refers to animals bred using the CRL International Genetic Standard system. COAT COLOR Albino.
Return to topXenoTech also offers subcellular fractions of pulmonary tissue from the following toxicologically significant species:
Return to topPRODUCTS
Product No. |
Product |
Gender |
Amount |
R1000.P |
Pooled IGS Sprague-Dawley Rat Pulmonary Microsomes |
Male |
0.5 mL at 10 mg/mL |
R1000.PS9 |
Pooled IGS Sprague-Dawley Rat Pulmonary S9 Fraction |
Male |
1.0 mL at 5 mg/mL |
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Order E-mail: info@xenotechllc.com
Call 877.588.7530 (toll-free US and Canada) for pricing and availability.
If ordering outside of North America, please see our Distributor information.