Fischer 344 Rat Subcellular Fractions
View Products XenoTech offers pooled liver
microsomes,
S9 fractions and
cytosol from sexually-mature male and female Fischer 344 rats.
DESCRIPTIONPACKAGINGCHARACTERIZATION PROVIDEDPRODUCT DETAILSPRODUCTSDESCRIPTION
Liver microsomes contain cytochromes P450, flavin-monooxygenases, carboxylesterases, epoxide hydrolase, UDP-glucuronosyltransferases and other drug-metabolizing enzymes, and are intended for use in
in vitro studies of xenobiotic metabolism.
The
S9 fraction is a mixture of microsomes and cytosol. Accordingly, it contains a wide variety of Phase 1 and Phase 2 enzymes including P450 enzymes, flavin-monooxygenases, carboxylesterases, epoxide hydrolase, UDP-glucuronosyltransferases, sulfotransferases, methyltransferases, acetyltransferases, glutathione
S‑transferases and other drug-metabolizing enzymes.
Liver cytosol contains many xenobiotic metabolizing enzymes including carboxylesterases, soluble epoxide hydrolases, alcohol dehydrogenases, aldehydes oxidases, xanthine oxidases, diamine oxidases, sulfotransferases, glutathione
S‑transferases, etc.
Return to topPACKAGING
MicrosomesConcentration: 20 mg/mL
Suspension buffer: 250 mM sucrose
S9 fractionConcentration: 20 mg/mL
Suspension buffer: 50 mM TRIS
·HCl (pH 7.4 at 4°C) containing 150 mM KCl and 2 mM EDTA
CytosolConcentration: 10 mg/mL
Suspension buffer: 50 mM TRIS
·HCl (pH 7.4 at 4°C) containing 150 mM KCl and 2 mM EDTA
Return to topCHARACTERIZATION PROVIDED
The following lot-specific product information is included with each order of non-human liver microsomes.
- Specific content of cytochrome P450
- Specific content of cytochrome b5
- NADPH-cytochrome c reductase activity
- 7-Ethoxycoumarin O-dealkylation
- Animal Information and Husbandry
Return to topPRODUCT DETAILS
NOMENCLATURE F344/CrCrlBR
ORIGIN Curtis and Dunning in 1920 at Columbia University Institute for Cancer Research. To Heston in 1949. To National Institutes of Health in 1951. To CRL in 1998.
COAT COLOR Albino.
Return to topPRODUCTS
Product No. |
Product |
Gender |
Amount |
R2000 |
Pooled Fischer 344 Rat Liver Microsomes |
Male |
0.5 mL at 20 mg/mL |
R2000.S9 |
Pooled Fischer 344 Rat Liver S9 Fraction |
Male |
1.0 mL at 20 mg/mL |
R2000.C |
Pooled Fischer 344 Rat Liver Cytosol |
Male |
1.0 mL at 10 mg/mL |
R2500 |
Pooled Fischer 344 Rat Liver Microsomes |
Female |
0.5 mL at 20 mg/mL |
R2500.S9 |
Pooled Fischer 344 Rat Liver S9 Fraction |
Female |
1.0 mL at 20 mg/mL |
R2500.C |
Pooled Fischer 344 Rat Liver Cytosol |
Female |
1.0 mL at 10 mg/mL |
Return to TopOrder Fax: 913.227.7171
Order E-mail: info@xenotechllc.com
Call 877.588.7530 (toll-free US and Canada) for pricing and availability.
If ordering outside of North America, please see our Distributor information.