Cryopreserved CD-1 Mouse Hepatocytes

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Upon thawing, cryopreserved mouse hepatocytes remain viable and may be used in suspension for short-term drug metabolism experiments (we recommend incubations no longer than four hours). When cryopreserved mouse hepatocytes are thawed, isolated and suspended under appropriate conditions, they can be used to evaluate the in vitro metabolism of drug candidates.

Please note that XenoTech does not recommend cryopreserved mouse hepatocytes for use in culture because their attachment to cell culture dishes is unpredictable.

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NOMENCLATURE Crl:CD-1® (ICR) BR ORIGIN The original group of Swiss mice that served as progenitors of this stock consisted of two male and seven female albino mice derived from a non-inbred stock in the laboratory of Dr. de Coulon, Centre Anticancereux Romand, Lausanne, Switzerland. These animals were imported into the United States by Dr. Clara Lynch of the Rockefeller Institute in 1926. The Hauschka Ha/ICR stock was initiated in 1948 at the Institute for Cancer Research in Philadelphia from "Swiss" mice of Rockefeller origin. To Dr. Edward Mirand of Roswell Park Memorial Institute where they were designated as HaM/ICR. To CRL in 1959 and caesarean rederived that same year. COAT COLOR Albino.

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We recommend our Mouse Hepatocyte Isolation Kit (K2100) to prepare and isolate our cryopreserved mouse hepatocytes. The use of this kit assures the highest quality preparation for your incubations.

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