Products
- Antibodies
- bDNA Probe Sets
- Custom Products
- Hepatocytes
- Kits
- Media
- P450 Substrates and Metabolites
- Recombinant Enzymes
- Subcellular Fractions
- Transporter Products
- XenoTech Promotions
Liver Alert
Sign up to receive E-mail notifications when fresh hepatocytes become available.Register now.
Order Product
Know what you want? Get started right now. Click Here.
Request a Quote
Contact one of our service professionals for a fast and reliable quote. Get started.
Calendar of Events
| Date | Event Name |
|---|---|
| Sep 13 - 17, 2010 | Land O'Lakes Drug Metabolism |
| Nov 14 - 18, 2010 | AAPS 2010 |
CryostaX Single-Freeze Pooled Human Hepatocytes
PackagingCharacterization ProvidedRelated Products
CryostaX™ is the largest multi-donor pool available prepared using a single-freeze process.
Pooled human hepatocytes are a preferred test system in many drug discovery and development applications. Like other pooled human hepatocytes, this pool of 10 or 20 provides you with a representative population sample for predictable results; however, our unique process allows pooling after only one freeze.
Availability of large lots assures long-term reliable results. Each vial contains one pellet (100 uL each) of each donor (n=10 or 20). Each individual is significantly represented in the final preparation. Assured minimum yield (AMY) is 5 million for the 10 donor pool and 10 million cells for the 20 donor pool. We recommend you use our Hepatocyte isolation kit [K2000] for the best results.
Download the datasheet for CryostaX™ here! (Pool of 10)
Downlaod the datasheet for CryostaX™ here! (Pool of 20)
Features:
- Single freeze process
- 10 or 20 donor lots available
- Large lots
- High-quality data
- Convenient
- Cost-saving (versus pooling your own)
- Allows for future customization of human hepatocytes
Packaging
10-Donor Pool:
- 10 x 100uL = 1.0mL total volume
- AMY: 5 million cells
20-Donor Pool:
- 20 x 100µL = 2.0mL total volume
- AMY: 10 million cells
Characterization Provided
- % viability
- CYP1A2 Phenacetin O-dealkylation
- CYP2A6 Coumarin 7-hydroxylation
- CYP2B6 Bupropion hydroxylation
- CYP2C8 Amodiaquine N-dealkylation
- CYP2C9 Diclofenac 4´-hydroxylation
- CYP2C19 S-Mephenytoin 4´-hydroxylation
- CYP2D6 Dextromethorphan O-demethylation
- CYP2E1 Chlorzoxazone 6-hydroxylation
- CYP3A4/5 Testosterone 6β-hydroxylation
- CYP3A4 Midazolam 1´-hydroxylation
- UGT 7-Hydroxycoumarin glucuronidation
- SULT 7-Hydroxycoumarin sulfonation
Donor information (age, ethnicity, gender, cause of death and infectious disease status)
Related Products
K2000 Hepatocyte Isolation Kit
Products
| Product # | Name | Gender | Amount | Assured Minimum Yield |
| HPCH10 | CryostaX™; Single-freeze Cryopreserved Pooled Human Hepatocytes; 10 donors | Mixed | 1.0 mL | 5.0 million cells |
| HPCH20 | CryostaX™; Single-freeze Cryopreserved Pooled Human Hepatocytes; 20 donors | Mixed | 2.0 mL | 10 million cells |
