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Calendar of Events
| Date | Event Name |
|---|---|
| Feb 23, 2012 | Webinar: FDA updates |
| Feb 27 - 29, 2012 | Clinically Relevant Drug Transporters |
| Mar 12 - 14, 2012 | SOT 2012 |
| May 6 - 8, 2012 | DDI Marbach Castle |
Beagle Dog Lung Subcellular Fractions
PackagingCharacterization ProvidedRelated Products
As the primary site for the entrance of airborne agents, and as the recipient of all cardiac output, the lungs may provide both first-pass and systemic metabolism of xenobiotics through several enzymatic pathways including both cytochrome P450 and Phase 2 enzymes.
Packaging
Microsomes
Concentration: 10 mg/mL
Suspension buffer: 250 mM sucrose
S9 fraction
Concentration: 5 mg/mL
Suspension buffer: 50 mM TRIS·HCl (pH 7.4 at 4°C) containing 150 mM KCl and 2 mM EDTA
Characterization Provided
XenoTech's lung subcellular fractions are characterized for the following activities:
- NADPH-cytochrome c reductase
- 7-Ethoxyresorufin O-dealkylation
- 4-Methylumbelliferone glucuronidation
Related Products
XenoTech also offers subcellular fractions of pulmonary tissue from the following toxicologically significant species:
- Human
- Cynomolgus monkey
- IGS Sprague-Dawley rat
Products
| Product # | Name | Gender | Amount |
| D1000.P | Pooled Beagle Dog Pulmonary Microsomes | Male | 0.5 mL at 10 mg/mL |
| D1000.PS9 | Pooled Beagle Dog Pulmonary S9 Fraction | Male | 1.0 mL at 5 mg/mL |
