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Calendar of Events
| Date | Event Name |
|---|---|
| Feb 23, 2012 | Webinar: FDA updates |
| Feb 27 - 29, 2012 | Clinically Relevant Drug Transporters |
| Mar 12 - 14, 2012 | SOT 2012 |
| May 6 - 8, 2012 | DDI Marbach Castle |
Hartley Albino Guinea Pig Subcellular Fractions
PackagingCharacterization ProvidedProduct Details
View microsome lot information and characterization data here!
View S9 lot information and characterization data here!
Liver microsomes contain cytochromes P450, flavin-monooxygenases, carboxylesterases, epoxide hydrolase, UDP-glucuronosyltransferases and other drug-metabolizing enzymes, and are intended for use in in vitro studies of xenobiotic metabolism.
The S9 fraction is a mixture of microsomes and cytosol. Accordingly, it contains a wide variety of Phase 1 and Phase 2 enzymes including P450 enzymes, flavin-monooxygenases, carboxylesterases, epoxide hydrolase, UDP-glucuronosyltransferases, sulfotransferases, methyltransferases, acetyltransferases, glutathione S-transferases and other drug-metabolizing enzymes.
Liver cytosol contains many xenobiotic metabolizing enzymes including carboxylesterases, soluble epoxide hydrolases, alcohol dehydrogenases, aldehydes oxidases, xanthine oxidases, diamine oxidases, sulfotransferases, glutathione S-transferases, etc.
Packaging
Microsomes
Concentration: 20 mg/mL
Suspension buffer: 250 mM sucrose
S9 fraction
Concentration: 20 mg/mL
Suspension buffer: 50 mM TRIS·HCl (pH 7.4 at 4°C) containing 150 mM KCl and 2 mM EDTA
Cytosol
Concentration: 10 mg/mL
Suspension buffer: 50 mM TRIS·HCl (pH 7.4 at 4°C) containing 150 mM KCl and 2 mM EDTA
Characterization Provided
The following lot-specific product information is included with each order of non-human liver microsomes.
- Specific content of cytochrome P450
- Specific content of cytochrome b5
- NADPH-cytochrome c reductase activity
- 7-Ethoxycoumarin O-dealkylation
- Animal Information and Husbandry
Product Details
NOMENCLATURE Crl:(HA)BR ORIGIN To CRL in 1968 from Medical Research Council, Millhill, England. Caesarean rederived in 1969. COAT COLOR Albino.
Products
| Product # | Name | Gender | Amount |
| G1000 | Pooled Hartley Albino Guinea Pig Liver Microsomes | Male | 0.5 mL at 20 mg/mL |
| G1000.C | Pooled Hartley Albino Guinea Pig Liver Cytosol | Male | 1.0 mL at 10 mg/mL |
| G1000.S9 | Pooled Hartley Albino Guinea Pig Liver S9 Fraction | Male | 1.0 mL at 20 mg/mL |
