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Calendar of Events
| Date | Event Name |
|---|---|
| Sep 13 - 17, 2010 | Land O'Lakes Drug Metabolism |
| Nov 14 - 18, 2010 | AAPS 2010 |
Cynomolgus Monkey Treated Subcellular Fractions
XenoTech provides hepatic microsomes from Cynomolgus monkeys treated with prototypical inducers to serve as positive controls for ex vivo enzyme induction studies.
These products are pooled from multiple animals to ensure good representation of the inducer and to provide sufficient product availability.
The following lot-specific product information is included with each order of microsomes:
• Specific content of cytochrome P450
• Specific content of cytochrome b5
• NADPH-cytochrome c reductase activity
• Activity of the inducible CYP enzyme
• Dosing regimen
• Animal husbandry conditions
Induction of specific cytochrome P450 enzymes are obtained through the treatment of mokeys with the following prototypical inducers.
• Saline (control)
• Phenobarbital
• β-Naphthoflavone
• Pyrazole
• Rifampin
• Omeprazole
Packaging
0.5mL at 10mg/mL
Products
| Product # | Name | Gender | Amount | Induced CYP Control |
| P2073 | Saline-treated liver microsomes | Male | 0.5mL @ 10mg/mL | no induction |
| P2078 | Phenobarbital-treated liver microsomes | Male | 0.5mL @ 10/mg/mL | induced CYP2A and CYP2B |
| P2083 | BNF-treated liver microsomes | Male | 0.5mL @ 10mg/mL | induced CYP1A |
| P2085 | Pyrazole-treated liver microsomes | Male | 0.5mL @ 10mg/mL | induced CYP2E |
| P2095 | Rifampin-treated liver microsomes | Male | 0.5mL @ 10mg/mL | induced CYP3A |
| P2096 | Omeprazole-treated liver microsomes | Male | 0.5mL @ 10mg/mL | induced CYP1A |
| P2573 | Saline-treated liver microsomes | Female | 0.5mL @ 10mg/mL | no induction |
| P2578 | Phenobarbital-treated liver microsomes | Female | 0.5mL @ 10mg/mL | induced CYP2A and CYP2B |
| P2583 | BNF-treated liver microsomes | Female | 0.5mL @ 10mg/mL | induced CYP1A |
| P2585 | Pyrazole-treated liver microsomes | Female | 0.5mL @ 10mg/mL | induced CYP2E |
| P2595 | Rifampin-treated liver microsomes | Female | 0.5mL @ 10mg/mL | induced CYP3A |
| P2596 | Omeprazole-treated liver microsomes | Female | 0.5mL @ 10mg/mL | induced CYP1A |
