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Cynomolgus Monkey Treated Subcellular Fractions
XenoTech provides hepatic microsomes from Cynomolgus monkeys treated with prototypical inducers to serve as positive controls for ex vivo enzyme induction studies.
These products are pooled from multiple animals to ensure good representation of the inducer and to provide sufficient product availability.
The following lot-specific product information is included with each order of microsomes:
• Specific content of cytochrome P450
• Specific content of cytochrome b5
• NADPH-cytochrome c reductase activity
• Activity of the inducible CYP enzyme
• Dosing regimen
• Animal husbandry conditions
Induction of specific cytochrome P450 enzymes are obtained through the treatment of mokeys with the following prototypical inducers.
• Saline (control)
0.5mL at 10mg/mL
|Product #||Name||Gender||Amount||Induced CYP Control|
|P2073||Liver microsomes from Saline-treated Cynomolgus monkey||Male||0.5mL @ 10mg/mL||no induction|
|P2078||Liver microsomes from Phenobarbital-treated Cynomolgus monkey||Male||0.5mL @ 10/mg/mL||induced CYP2A and CYP2B|
|P2083||Liver microsomes from BNF-treated Cynomolgus monkey||Male||0.5mL @ 10mg/mL||induced CYP1A|
|P2085||Liver microsomes from Pyrazole-treated Cynomolgus monkey||Male||0.5mL @ 10mg/mL||induced CYP2E|
|P2095||Liver microsomes from Rifampin-treated Cynomolgus monkey||Male||0.5mL @ 10mg/mL||induced CYP3A|
|P2096||Liver microsomes from Omeprazole-treated Cynomolgus monkey||Male||0.5mL @ 10mg/mL||induced CYP1A|
|P2573||Liver microsomes from Saline-treated Cynomolgus monkey||Female||0.5mL @ 10mg/mL||no induction|
|P2578||Liver microsomes from Phenobarbital-treated Cynomolgus monkey||Female||0.5mL @ 10mg/mL||induced CYP2A and CYP2B|
|P2583||Liver microsomes from BNF-treated Cynomolgus monkey||Female||0.5mL @ 10mg/mL||induced CYP1A|
|P2585||Liver microsomes from Pyrazole-treated Cynomolgus monkey||Female||0.5mL @ 10mg/mL||induced CYP2E|
|P2595||Liver microsomes from Rifampin-treated Cynomolgus monkey||Female||0.5mL @ 10mg/mL||induced CYP3A|
|P2596||Liver microsomes from Omeprazole-treated Cynomolgus monkey||Female||0.5mL @ 10mg/mL||induced CYP1A|