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Calendar of Events
| Date | Event Name |
|---|---|
| May 23, 2012 | Webinar: PBPK modeling |
MDR1 Unlabeled Probe Substrate-NMQ
N-methyl-quinidine (NMQ), a low permeabily amphipathic monoquaternary molecule is an excellent cationic model compound. NMQ was shown to be actively transported by human MDR1/P-gp and rat Mdr1b efflux transporters (Hooiveld et al, 2002) as well as by the human OATP-A (OATP1A2) uptake transporter (van Montfoort et al, 1999). The apparent Km values were 15 µM, 20 µM and 26 µM for the MDR1, Mdr1b and OATP-A transporters, respectively.
NMQ:
Kinetic parameters of human MDR1- and rat Mdr1b-mediated NMQ transport into transporter containing and control membrane vesicles have been validated using SOLVO membrane preparations (SB-MDR1-K-VT, SB-K-CTRL, SB-ratMdr1b-Sf9-VT, SB-defPgp-Sf9-VT). The human MDR1 transporter was expressed in mammalian cells (MDR1-K), while the rat Mdr1b transporter was expressed in Sf9 cells using baculoviral infection system (ratMdr1b-Sf9).
Products
| Product # | Name | Amount |
| SB-NMQ-1 | SB-P-gp/MDR1 Substrate | 5 mg |
| SB-NMQ-2 | SB-P-gp/MDR1 Substrate | 10 mg |
| SB-NMQ-3 | SB-P-gp/MDR1 Substrate | 50 mg |
| SB-NMQ-4 | SB-P-gp/MDR1 Substrate | 100 mg |
| SB-NMQ-5 | SB-P-gp/MDR1 Substrate | 500 mg |
| SB-NMQ-6 | SB-P-gp/MDR1 Substrate | 1 G |
