PreadyPort

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NOW AVAILABLE FOR BCRP!

SOLVO Biotechnology introduces PreadyPort^TM in collaboration with ADVANCELL. PreadyPort^TM is a new ready-to-use transfected MDCKII monolayer concept for your in vitro drug transport evaluations.

Monolayer assays using transfected MDCKII cells are widely recognized tools to study the interaction of drugs with efflux and/or uptake transporters. The monolayer system is suitable for performing both inhibition and substrate assessments and is often used to model the net transport events of important fluid compartment barriers in the organism that express a specific transporter at a high level (e.g. MDR1/P-gp in the blood-brain-barrier).

PreadyPort^TM MDR1 Kits contain 24- or 96-well cell culture insert plates with differentiated MDCKII cells expressing MDR1, as well as the parental cell line. The innovative shipping medium, developed and patented by ADVANCELL, preserves the properties of the barrier throughout transportation, allowing us to provide customers with a robust, ready-to-use drug transport assay kit.

Click Here to download the PreadyPort™ flyer!

The first member of the PreadyPort^TM series, the PreadyPort^TM-MDR1 Kit is revolutionary in providing a ready-to-use tool for MDCKII-MDR1 monolayer assays. The kit will allow researchers to perform MDR1 interaction studies on monolayers without bothering about cell-line licensing and culturing.

Applications:
- MDR1 substrate assessment (direct transport studies)
- MDR1 inhibitor assessment (drug-drug interaction studies)
- Models the net transport events of barriers like the human blood-brain-barrier and the intestine

Product Details

For detailed information on the PreadyPort™-MDR1 Kit and validation data, please click here.

We highly recommend reading the Chemicals and Instruments needed and the Tips for Success guide before the arrival of the ordered PreadyPort™ Kits.

The PreadyPort™ product line will be extended with MDCKII-BCRP and MDCKII-OATPB/BCRP in the near future.

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