XenoTech, LLC - Publications

Covalent Binding

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Leone AM, Kao LM, McMillian MK, Nie AY, Parker JB, Kelley MF, Usuki EU, Parkinson A, Lord PG and Johnson MD (2007) Evaluation of Felbamate and Other Antiepileptic Drug Toxicity Potential Based on Hepatic Protein Covalent Binding and Gene Expression. Chem Res Toxicol 20:600-608.
Hoch U and Ortiz de Montellano PR (2001) Covalently linked heme in cytochrome P4504a fatty acid hydroxylases. J Biol Chem 276 11339-11346.
Van Heek M, Schmitt D, Toren P, Cathcart MK and DiCorleto PE (1998) Cholesteryl hydroperoxyoctadecadienoate from oxidized low density lipoprotein inactivates platelet-derived growth factor. J Biol Chem 273:19405-19410.
Madan A and Parkinson A (1996) Characterization of the NADPH-dependent covalent binding of [14C]-halothane to human liver microsomes: a role for CYP2E1 at low substrate concentrations. Drug Metab Dispos 24:1307-1313.
Mani C, Pearce R, Parkinson A and Kupfer D (1994) Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes. Carcinogenesis 15:2715-2720.