XenoTech, LLC - Publications

Effect of Solvents on P450 Enzymes

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Easterbrook J, Lu C, Sakai Y and Li A (2001) Effects of Organic Solvents on the Activities of Cytochrome Isoforms, UDP-Dependent Glucuronyl Transferase, and Phenol Sulfotransferase in Human Hepatocytes. Drug Metab and Dispos 29:141-144.
Busby WF, Ackermann JM and Crespi CL (1999) Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochrome P450. Drug Metab Dispos 27:246-249.
Chauret N, Gauthier A and Nicolle-Griffith DA (1998) Effect of common organic solvents on in vitro cytochrome P450-mediated metabolic activities in human liver microsomes. Drug Metab Dispos 27:1-4.
Hickman D, Wang JP and Unadkat JD (1998) Evaluation of the selectivity of in vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities. Drug Metab Dispos 26:207-215.
Draper A, Madan A and Parkinson A (1996) Inhibition of coumarin 7-hydroxylation (CYP2A6) by commonly used P450 inhibitors. Arch Biochem Biophys 341:47-61.