XenoTech, LLC - Publications

Function of Drug-Metabolizing Enzymes

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Buters JTM and Doehmer J (1999) Cytochrome P450-null mice. Drug Metab Rev 31:437-447.
Chang GWM and Kam PCA (1999) The physiological and pharmacological roles of cytochrome P450 isoenzymes. Anaesthesia 54:42-50.
Crespi CL and Miller VP (1999) The use of heterologously expressed drug metabolizing enzymes-state of the art and prospects for the future. Pharmacol Ther 84:121-131.
Estabrook RW (1999) Discovering the functions of cytochrome P450 in drug metabolism: the role of Alfred Hildebrandt. Drug Metab Rev 31:317-331.
Wormhoudt LW, Commandeur JN and Vermeulen NP (1999) Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity. Crit Rev Toxicol 29:59-124.
Honkakoski P and Negishi M (1997) The structure, function and regulation of cytochrome P450 2A enzymes. Drug Metab Rev 29:997-1096.
Rendic S and Di Carlo FJ (1997) Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab Rev 29:413-580.
Graham-Lorence S and Peterson JA (1996) P450s: structural similarities and functional differences. FASEB J 10:206-214.
Negishi M, Uno T, Darden TA, Sueyoshi T and Pedersen LG (1996) Structural flexibility and functional versatility of mammalian P450 enzymes. FASEB J 10:683-689.