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Hepatocytes

Ascendingitem name
Madan A, Graham R, Carroll K, Mudra D, Burton L, Krueger L, Downey A, Czerwinski M, Forster J, Ribadeneira M, Gan L, LeCluyse E, Zech K, Robertson P, Koch P, Antonian L, Wagner G, Yu L and Parkinson A
(2003) Effects of prototypical microsomal enzyme inducers on cytochrome P450 (CYP) expression in cultured human hepatocytes. Drug Metab and Dispos 31:421-431.
Zhang J, Huang W, Chua SS, Wei P and Moore DD
(2002) Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science 298: 422-424.
Hengstler JG, Ringel M, Biefang K, Diener B, Platt K, Böttger T, Steinberg P and Oesch F
(2000) Cultures with cryopreserved hepatocytes applicability for studies of enzyme induction. Chem Biol Interact 125:51-73.
LeCluyse E, Madan A, Hamilton G, Carroll K, DeHaan R and Parkinson A
(2000) Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. J Biochem Molecular Tox 14:177-188.
LeCluyse E, Bullock P, Madan A, Carroll K and Parkinson A
(1999) Influence of extracellular matrix overlay and medium formulation on the induction of cytochrome P450 2B enzymes in primary cultures of rat hepatocytes. Drug Metab Dispos 27: 909-915.
Li AP, Gorycki PD and Hengstler JG
(1999) Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel. Chem Biol Interact 121:117-123.
Silva JM, Day SH and Nicoll-Griffith DA
(1999) Induction of cytochrome-P450 in cryopreserved rat and human hepatocytes. Chem Biol Interact 121:49-63.
Steinberg P, Fisher T, Kiulies B, Biefang K, Platt KL, Oesch F, Böttger T, Bulitta C, Kempf P and Hengstler J
(1999) Drug metabolizing capacity of cryopreserved human, rat and mouse liver parenchymal cells in suspension. Drug Metab Dispos 27:1415-1422.
Houston JB and Carlile DJ
(1997) Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices. Drug Metab Rev 29:891-922.
Borchardt RT, Smith PL and Wilson G
Models for assessing drug absorption and metabolism. Pharmaceutical Technology, Vol 8, 1996.
Ekins S
(1996) Past, present, and future applications of precision-cut liver slices for in vitro xenobiotic metabolism. Drug Metab Rev 28:591-623.
LeCluyse E, Bullock P and Parkinson A
(1996) Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes. Adv Drug Delivery Rev 22:133-186.
Swales NJ, Johnson T and Caldwell J
(1996) Cryopreservation of rat and mouse hepatocytes. II. Assessment of metabolic capacity using testosterone metabolism. Drug Metab Dispos 24:1224-1230.
Swales NJ, Luong C and Caldwell J
(1996) Cryopreservation of rat and mouse hepatocytes. I. Comparative viability studies. Drug Metab Dispos 24:1218-1223.
Diener B and Oesch F
(1995) Cryopreserved and hypothermically stored rat liver parenchymal cells as metabolizing system in the Salmonella mutagenicity assay. Mutat Res 335:309-316.
Diener B, Abdel-Latif H, Arand M and Oesch F
(1995) Xenobiotic metabolizing enzyme activities and viability are well preserved in EDTA-isolated rat liver parenchymal cells after cryopreservation. Toxicol Appl Pharmacol 130:149-153.
Ekins S, Murray GI, Burke MD, Williams JA, Marchant NC and Hawksworth GM
(1995) Quantitative differences in Phase I and II metabolism between rat precision-cut liver slices and isolated hepatocytes. Drug Metab Dispos 23:1274-1279.
Kocarek TA, Schuetz EG and Guzelian PS
(1993) Expression of multiple forms of cytochrome P450 mRNAs in primary cultures of rat hepatocytes maintained on matrigel. Mol Pharmacol 43: 328-334.
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