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Immortalized Hepatocytes

Ascendingitem name
Lyon K, Czerwinski M, Perry M, Toren P and Parkinson A.
The Use of Immortalized Hepatocytes in Induction Studies. Abstract 1685 (Presented at SOT meeting, Baltimore, Maryland, March 2004).
Mills JB, Rose KA, Sadagopan N, Sahi J and de Morais SM
(2004) Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line. J Pharmacol Exp Ther 309:303-309.
Bjornsson TD, Callaghan JT, Einolf HJ, Fischer V, Gan L, Grimm S, Kao J, King SP, Miwa G, Ni L, Kumar G, McLeod J, Obach SR, Roberts S, Roe A, Shah A, Snikeris F, Sullivan JT, Tweedie D, Vega JM, Walsh J and Wrighton SA
(2003) The conduct of in vitro and in vivo drug-drug interaction studies: A PhRMA perspective.  J Clin Pharmacol  43:443-469.
Czerwinski M, Lyon K, Perry M, Toren P, Steen D, Settle K and Parkinson A
Induction of Major Cytochrome P450 Enzymes in Immortalized Human Hepatocytes.  Drug Metab. Rev. 35: 125, 2003. Abstract  462  (Presented at the annual ISSX meeting, Providence, Rhode Island, October 2003).
Madan A, Graham R, Carroll K, Mudra D, Burton L, Krueger L, Downey A, Czerwinski M, Forster J, Ribadeneira M, Gan L, LeCluyse E, Zech K, Robertson P, Koch P, Antonian L, Wagner G, Yu L and Parkinson A
(2003) Effects of prototypical microsomal enzyme inducers on cytochrome P450 (CYP) expression in cultured human hepatocytes. Drug Metab and Dispos 31:421-431.
Morris AL, Awwal E, and Frank KB
In vitro induction of cytochrome P450s and drug transporters using the Fa2N-4 immortalized human hepatocyte line. Drug. Metab. Rev.  35: 125, 2003. Abstract 249.  (Presented at the annual ISSX meeting, Providence, Rhode Island, October 2003).
Luo G, Cunningham M, Kim S, Burn T, Lin J, Sinz M, Hamilton G, Rizzo C, Jolley S, Gilbert D, Downey A, Mudra D, Graham R, Carroll K, Xie J, Madan A, Parkinson A, Christ D, Selling B, LeCluyse E and Gan L
(2002) CYP3A4 induction by drugs: correlation between a pregnane x receptor reporter gene assay and CYP3A4 expression in human hepatocytes. Drug Metab and Dispos 30:795-804.
Mudra DR and Parkinson A
(2001) Preparation of hepatocytes for drug metabolism stud­ies, in: Current Protocols in Toxicology (Maines M, Brad-field C, Costa L, Hodgson E, Reed D and Sipes IG eds). Unit 5.8., John Wiley & Sons, Inc., New Your, NY.
Parkinson A
(2001) Biotransformation of Xenobiotics, in:  Casarett & Doull’s Toxicology: The Basic Science of Poisons (Klaassen CD ed), pp 133-224, McGraw-Hill, Inc.,  New York City, NY.
Tucker GT, Houston JB and Huang SM
(2001) Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential – toward a consensus. Pharm Res 18:1071-1080.
LeCluyse E, Madan A, Hamilton G, Carroll K, DeHaan R and Parkinson A
(2000) Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. J Biochem Molecular Tox 14:177-188.
Levy R, Thummel K, Trager W, Hansten P and Eichelbaum M
(2000) Metabolic Drug Interactions, Lippincott, William & Wilkins, Philadelphia, PA.
LeCluyse E, Bullock P, Madan A, Carroll K and Parkinson A
(1999) Influence of extracellular matrix overlay and medium formulation on the induction of cytochrome P450 2B enzymes in primary cultures of rat hepatocytes. Drug Metab Dispos 27: 909-915.
Madan A, DeHaan R, Mudra D, Carroll K, LeCluyse E and Parkinson A
(1999) Effect of cryopreservation on cytochrome P450 enzyme induction in cultured rat hepato­cytes. Drug Metab Dispos 27:327-335.
Draper AJ, Madan A, Latham J and Parkinson A
(1998) Development of a non-HPLC assay to determine [14C]-chlorzoxazone 6-hydroxylase (CYP2E1) activity in human liver microsomes. Drug Metab Dispos 26:305-312.
LeCluyse E, Bullock P, Parkinson A and Hochman J
(1996) Cultured rat hepatocytes. In: Models for assessing Drug Absorption and Metabolism (Borchard RT, Smith PL and Wilson G eds), pp 121-160, Plenum Press, New York. 
LeCluyse E, Bullock P and Parkinson A
(1996) Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes. Adv Drug Delivery Rev 22:133-186.
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