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Induction

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Bjornsson TD, Callaghan JT, Einolf HJ, Fischer V, Gan L, Grimm S, Kao J, King SP, Miwa G, Ni L, Kumar G, McLeod J, Obach SR, Roberts S, Roe A, Shah A, Snikeris F, Sullivan JT, Tweedie D, Vega JM, Walsh J and Wrighton SA
(2003) The conduct of in vitro and in vivo drug-drug interaction studies: A PhRMA perspective.  J Clin Pharmacol  43:443-469.
Madan A, Graham R, Carroll K, Mudra D, Burton L, Krueger L, Downey A, Czerwinski M, Forster J, Ribadeneira M, Gan L, LeCluyse E, Zech K, Robertson P, Koch P, Antonian L, Wagner G, Yu L and Parkinson A
(2003) Effects of prototypical microsomal enzyme inducers on cytochrome P450 (CYP) expression in cultured human hepatocytes. Drug Metab and Dispos 31:421-431.
Graham R, Downey A, Mudra D, Krueger L, Carroll K, Chengelis C, Madan A and Parkinson A
(2002) In vivo and in vitro induction of cytochrome P450 (CYP) enzymes in beagle dogs. Drug Metab Dispos 30:1206-1213.
Luo G, Cunningham M, Kim S, Burn T, Lin J, Sinz M, Hamilton G, Rizzo C, Jolley S, Gilbert D, Downey A, Mudra D, Graham R, Carroll K, Xie J, Madan A, Parkinson A, Christ D, Selling B, LeCluyse E and Gan L
(2002) CYP3A4 induction by drugs: correlation between a pregnane x receptor reporter gene assay and CYP3A4 expression in human hepatocytes. Drug Metab and Dispos 30:795-804.
Robertson P, DeCory HH, Madan A and Parkinson A
(2000) In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil. Drug Metab Dispos 28:664-671.
Lehman-McKeeman LD, Claudill D, Vasallo JD, Pearce RE, Madan A and Parkinson A
(1999) Effects of musk xylene and musk ketone on rat hepatic cytochrome P450 enzymes. Toxicol Lett 111:105-115.
McKim JM, Choudhuri S, Wilga PC, Madan A, Burns-Naas LA, Gallavan RH, Mast RW, Naas DJ, Parkinson A and Meeks RG
(1999) Induction of hepatic xenobiotic metabolizing enzymes in female Fischer-344 rats following repeated inhalation exposure to decamethylcyclopentasiloxane (D5). Toxicol Sci 50:10-19.
Dwyer-Neild LD, Thompson JA, Peljak G, Squier MK, Barker TD, Parkinson A, Cohen JJ, Dinsdale D and Malkinson AM
(1998) Selective induction of apoptosis in mouse and human lung epithelial cells by the tert-butyl hydroxylated metabolite of butylated hydroxytoluene: a proposed role in tumor promotion. Toxicology 130:115-127.
McKim JM Jr, Wilga PC, Kolesar GB, Choudhuri S, Madan A, Dochterman LW, Breen JG, Parkinson A, Mast RW and Meeks RG
(1998) Evaluation of octa­methyl­cyclo­tetra­siloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: a 28-day inhalation study. Toxicol Sci 41:29-41.
Sidhu JS, Marcus CB, Parkinson A and Omiecinski CJ
(1998) Differential induction of cytochrome P450 gene expression by 4n-alkyl-methylenedioxybenzenes in primary rat hepatocyte cultures. J Biochem Mol Toxicol 12:253-262.
Parkinson A, Madan A, Forster J, Carroll K, Marcucci K, DeHaan R and Lecluyse E
Enzyme Induction: Assessing the potential for drug interactions. In: Drug-Drug Interactions:  Analyzing in vitro-in vivo correlations. (Ed.: W. Hori). Chapter 1.7, pp. 1-33. International Business Communications, Inc. Massachusetts. 1997.
Thompson TN
(1997) Experimental models for evaluating enzyme induction potential of new drug candidates in animals and humans and a strategy for their use. Adv Pharmacol 43:205-229.
Bookstaff R, Murphy V, Skare J, Minnema D, Sanzgiri U and Parkinson A
(1996) Effects of doxylamine succinate on thyroid hormone balance and enzyme induction in mice. Toxicol Appl Pharmacol 141:584-594.
Forkert PG, Jackson AC, Parkinson A and Chen S
(1996) Diminished expression of CYP1A1 in urethane-induced lung tumors in strain A/J mice: analysis by in situ hybridization and immunohistochemical methods. Am J Respir Cell Mol Biol 14:444-453.
Bullock P, Pearce R, Draper A, Podvall J, Bracken W, Veltman J, Thomas P and Parkinson A
(1995) Induction of liver microsomal cytochrome P450 in Cynomolgus monkeys. Drug Metab Dispos 23:736-748.
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Thompson TN and Klaassen CD
(1995) The effects of microsomal enzyme inducers on the pharmacokinetics of ouabain after portal and systemic administration to rats. J Pharm Pharmacol 47:1041-1047.
Blouin RA, Bandyrpadhyay AM, Chandhary I, Robertson LW, Gemzik B and Parkinson A
(1993) Cytochrome P450 2B enzyme (CYP2B) induction defect following phenobarbital treatment in the fa/fa Zucker rat: Molecular characterization. Arch Biochem Biophys 303:312-320.
Parkinson A, Clement RP, Casciano CN and Cayen MN
(1992) Evaluation of loratadine as an inducer of liver microsomal cytochrome P450 in rats and mice. Biochem Pharmacol 43:2169-2180.
Parkinson A, Leonard N, Draper A and Ogilvie BW
(2006) On the mechanism of hepatocarcinogenesis of benzodiazepines: evidence that diazepam and oxazepam are CYP2B inducers in rats, and both CYP2B and CYP4A inducers in mice. Drug Metab Rev 38:235-259.
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