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Inhibition

Ascendingitem name
Ogilvie BW, Zhang D, Li W, Rodrigues AD, Gipson AE, Holsapple J, Toren P and Parkinson A
(2006) Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: Implications for drug-drug interactions. Drug Metab Dispos 34:191-197.
Bjornsson TD, Callaghan JT, Einolf HJ, Fischer V, Gan L, Grimm S, Kao J, King SP, Miwa G, Ni L, Kumar G, McLeod J, Obach SR, Roberts S, Roe A, Shah A, Snikeris F, Sullivan JT, Tweedie D, Vega JM, Walsh J and Wrighton SA
(2003) The conduct of in vitro and in vivo drug-drug interaction studies: A PhRMA perspective.  J Clin Pharmacol  43:443-469.
Robertson P, DeCory HH, Madan A and Parkinson A
(2000) In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil. Drug Metab Dispos 28:664-671.
Draper AJ, Madan A, Latham J and Parkinson A
(1998) Development of a non-HPLC assay to determine [14C]-chlorzoxazone 6-hydroxylase (CYP2E1) activity in human liver microsomes. Drug Metab Dispos 26:305-312.
Smith DA, Abel SM, Hyland R and Jones BC
(1998) Human cytochrome P450s: selectivity and measurement in vivo. Xenobiotica 28:1095-1128.
Draper A, Madan A and Parkinson A
(1996) Inhibition of coumarin 7-hydroxylation (CYP2A6) by commonly used P450 inhibitors. Arch Biochem Biophys 341:47-61.
Ogilvie BW, Usuki E, Yerino P and Parkinson A
(Forthcoming 2008) In vitro approaches for studying the inhibition of drug-metabolizing enzymes and identifying the drug-metabolizing enzymes responsible for the metabolism of drugs (reaction phenotyping) with emphasis on cytochrome P450, in:  Drug-Drug Interactions (Rodrigues AD ed), Informa Healthcare, New York, NY. In Press.
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