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Reaction Phenotyping

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Bjornsson TD, Callaghan JT, Einolf HJ, Fischer V, Gan L, Grimm S, Kao J, King SP, Miwa G, Ni L, Kumar G, McLeod J, Obach SR, Roberts S, Roe A, Shah A, Snikeris F, Sullivan JT, Tweedie D, Vega JM, Walsh J and Wrighton SA
(2003) The conduct of in vitro and in vivo drug-drug interaction studies: A PhRMA perspective.  J Clin Pharmacol  43:443-469.
Prakash C, Kamel A, Cui D, Whalen RD, Miceli JJ and Tweedie D
(2000) Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions. Br J Clin Pharmacol 49:35S-42S.
Granvil CP, Madan A, Sharkawi M, Parkinson A and Wainer IW
(1999) Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes. Drug Metab Dispos 27:533-541.
Draper AJ, Madan A, Latham J and Parkinson A
(1998) Development of a non-HPLC assay to determine [14C]-chlorzoxazone 6-hydroxylase (CYP2E1) activity in human liver microsomes. Drug Metab Dispos 26:305-312.
Draper AJ, Madan A, Smith K and Parkinson A
(1998) Development of a non-HPLC assay to determine testosterone hydroxylase (CYP3A) activity in human liver microsomes. Drug Metab Dispos 26:299-304.
Lee RP, Parkinson A and Forkert PG
(1998) Isozyme-selective metabolism of ethyl carbamate by cytochrome P450 (CYP2E1) and carboxylesterase (hydrolase A) enzymes in murine liver microsomes. Drug Metab Dispos 26:60-65.
Madan A, Parkinson A and Faiman MD
(1998) Identification of the human P450 enzymes responsible for the sulfoxidation and thio-oxidation of diethyldithiocarbamate methyl ester: Role of P450 enzymes in disulfiram metabolism. Alcoholism: Clin Exp Res 22:1212-1219.
Usuki E, Pearce R, Parkinson A and Castagnoli N Jr
(1996) Studies on the conversion of haloperidol and its tetrahydropyridine dehydration product to potentially neurotoxic pyridinium metabolites by human liver microsomes. Chem Res Toxicol 9:800-806.
Yumibe N, Huie K, Chen KJ, Snow M, Clement RP and Cayen MN
(1996) Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6. Biochem Pharmacol 51:165-172.
Madan A, Parkinson A and Faiman MD
(1995) Identification of the human and rat P450 enzymes responsible for the sulfoxidation S-methyl N,N,-diethylthiolcarbamate (DDTC-Me), the terminal step in the bioactivation of disulfiram. Drug Metab Dispos 23:1153-1162.
Madan A, Parkinson A and Faiman MD
(1993) Role of flavin-containing monooxygenases and P450 enzymes in the sulfoxidation of S-methyl N, N-diethylthiolcarbamate. Biochem Pharmacol 46:2291-2297.
Mani C, Gelboin HV, Pang SS, Pearce R, Parkinson A and Kupfer D
(1993) Metabolism of the antimammary cancer antiestrogen agent tamoxifen. I. Cytochrome P-450-catalyzed N-demethylation and 4-hydroxylation. Drug Metab Dispos 21:645-656.
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