XenoTech, LLC - Publications

Transporters

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Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I and Gottesman MM (1999) Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 39:361-398.
Hall SD, Thummel KE, Watkins PB, Lown KS, Benet LZ, Paine MF, Mayo RR, Turgeon DK, Bailey DG, Fontana RJ and Wrighton SA (1999) Molecular and physical examination of the first-pass extraction. Drug Metab Dispos 27:161-166.
Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ and Wilkinson GR (1999) Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res 16:408-414.
Smith DA and van de Waterbeemd H (1999) Pharmacokinetics and metabolism in early drug discovery. Curr Opin Chem Biol 3:373-378.
Wandel C, Kim RB, Kajiji S, Guengerich P, Wilkinson GR and Wood AJ (1999) P-glycoprotein and cytochrome P450 3A inhibition: dissociation of inhibitory potencies. Cancer Res 59:3944-3948.
Stieger B and Meier PJ (1998) Bile acid and xenobiotic transporters in liver. Curr Opin Cell Biol 10:462-467.
Wacher VJ, Silverman JA, Zhang Y and Benet LZ (1998) Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. J Pharm Sci 87:1322-1330.