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XenoTech Authored Publications

Ascendingitem name
Leone AM, Kao LM, McMillian MK, Nie AY, Parker JB, Kelley MF, Usuki EU, Parkinson A, Lord PG and Johnson MD
(2007) Evaluation of Felbamate and Other Antiepileptic Drug Toxicity Potential Based on Hepatic Protein Covalent Binding and Gene Expression.  Chem Res Toxicol 20:600-608.
Parkinson A, Mudra DR, Johnson C, Dwyer LA and Carroll K
(2004) The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes. Toxicol Appl Pharmacol 199:193-209.
Madan A, Graham R, Carroll K, Mudra D, Burton L, Krueger L, Downey A, Czerwinski M, Forster J, Ribadeneira M, Gan L, LeCluyse E, Zech K, Robertson P, Koch P, Antonian L, Wagner G, Yu L and Parkinson A
(2003) Effects of prototypical microsomal enzyme inducers on cytochrome P450 (CYP) expression in cultured human hepatocytes. Drug Metab and Dispos 31:421-431.
Luo G, Cunningham M, Kim S, Burn T, Lin J, Sinz M, Hamilton G, Rizzo C, Jolley S, Gilbert D, Downey A, Mudra D, Graham R, Carroll K, Xie J, Madan A, Parkinson A, Christ D, Selling B, LeCluyse E and Gan L
(2002) CYP3A4 induction by drugs: correlation between a pregnane x receptor reporter gene assay and CYP3A4 expression in human hepatocytes. Drug Metab and Dispos 30:795-804.
Madan A, Usuki E, Burton LA, Ogilvie BW and Parkinson A
(2002) In vitro approaches for studying the inhibition of drug-metabolizing enzymes and identifying the drug-metabolizing enzymes responsible for the metabolism of drugs, in: Drug-Drug Interactions (Rodrigues AD ed), pp 217-294, Marcel Dekker, Inc., New York, NY. 
Mudra DR and Parkinson A
(2001) Preparation of hepatocytes for drug metabolism stud­ies, in: Current Protocols in Toxicology (Maines M, Brad-field C, Costa L, Hodgson E, Reed D and Sipes IG eds). Unit 5.8., John Wiley & Sons, Inc., New Your, NY.
Parkinson A
(2001) Biotransformation of Xenobiotics, in:  Casarett & Doull’s Toxicology: The Basic Science of Poisons (Klaassen CD ed), pp 133-224, McGraw-Hill, Inc.,  New York City, NY.
LeCluyse E, Madan A, Hamilton G, Carroll K, DeHaan R and Parkinson A
(2000) Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. J Biochem Molecular Tox 14:177-188.
LeCluyse E, Bullock P, Madan A, Carroll K and Parkinson A
(1999) Influence of extracellular matrix overlay and medium formulation on the induction of cytochrome P450 2B enzymes in primary cultures of rat hepatocytes. Drug Metab Dispos 27: 909-915.
Lehman-McKeeman LD, Claudill D, Vasallo JD, Pearce RE, Madan A and Parkinson A
(1999) Effects of musk xylene and musk ketone on rat hepatic cytochrome P450 enzymes. Toxicol Lett 111:105-115.
Madan A, DeHaan R, Mudra D, Carroll K, LeCluyse E and Parkinson A
(1999) Effect of cryopreservation on cytochrome P450 enzyme induction in cultured rat hepato­cytes. Drug Metab Dispos 27:327-335.
McKim JM, Choudhuri S, Wilga PC, Madan A, Burns-Naas LA, Gallavan RH, Mast RW, Naas DJ, Parkinson A and Meeks RG
(1999) Induction of hepatic xenobiotic metabolizing enzymes in female Fischer-344 rats following repeated inhalation exposure to decamethylcyclopentasiloxane (D5). Toxicol Sci 50:10-19.
Dwyer-Neild LD, Thompson JA, Peljak G, Squier MK, Barker TD, Parkinson A, Cohen JJ, Dinsdale D and Malkinson AM
(1998) Selective induction of apoptosis in mouse and human lung epithelial cells by the tert-butyl hydroxylated metabolite of butylated hydroxytoluene: a proposed role in tumor promotion. Toxicology 130:115-127.
Lee RP, Parkinson A and Forkert PG
(1998) Isozyme-selective metabolism of ethyl carbamate by cytochrome P450 (CYP2E1) and carboxylesterase (hydrolase A) enzymes in murine liver microsomes. Drug Metab Dispos 26:60-65.
Madan A, Parkinson A and Faiman MD
(1998) Identification of the human P450 enzymes responsible for the sulfoxidation and thio-oxidation of diethyldithiocarbamate methyl ester: Role of P450 enzymes in disulfiram metabolism. Alcoholism: Clin Exp Res 22:1212-1219.
McKim JM Jr, Wilga PC, Kolesar GB, Choudhuri S, Madan A, Dochterman LW, Breen JG, Parkinson A, Mast RW and Meeks RG
(1998) Evaluation of octa­methyl­cyclo­tetra­siloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: a 28-day inhalation study. Toxicol Sci 41:29-41.
Van Heek M, Schmitt D, Toren P, Cathcart MK and DiCorleto PE
(1998) Cholesteryl  hydroperoxyoctadecadienoate from oxidized low density lipoprotein inactivates platelet-derived growth factor. J Biol Chem 273:19405-19410.
Parkinson A, Pearce R, Madan A and Forster J
(1997) Availability and preservation of human tissues, and the use of human liver microsomes in drug metabolism research. In: The Use of Human In Vitro Systems to Support Preclinical Safety Assessment. (eds. Sundwall A, Alvan G, Lindgren E, Moldeus P, Salmonsson T and Sjoberg P). 17-28 Tryckgruppen, Stockholm, Sweden.

LeCluyse E, Bullock P, Parkinson A and Hochman J
(1996) Cultured rat hepatocytes. In: Models for assessing Drug Absorption and Metabolism (Borchard RT, Smith PL and Wilson G eds), pp 121-160, Plenum Press, New York. 
LeCluyse E, Bullock P and Parkinson A
(1996) Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes. Adv Drug Delivery Rev 22:133-186.
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