Covalent Binding

XenoTech offers covalent binding studies through our partner company, Sekisui. As a screening tool for the idiosyncratic potential of drug candidates, chemical reactivity of the compound and its metabolites is often evaluated by quantifying covalent binding properties. Through Sekisui, we offer covalent binding studies to evaluate the binding characteristics of a compound using human and non-human hepatic proteins.

In a typical study, the amount of labeled compound and its metabolite(s) that covalently bind to protein is determined through an in vitro test system using human liver microsomes. Rats are then subjected to the induction of liver metabolic enzymes followed by administration of the labeled compound, with the liver being removed at a specific time point. Radioactivity in the plasma and liver is measured to obtain the amount of labeled compound and its metabolites that covalently bind to protein in these biological samples in vitro.

Download our flyer on Plasma Protein and Covalent Binding here.

If you are interested in placing a covalent binding study, please contact our customer service group here.