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Calendar of Events

Date Event Name
May 23, 2012 Webinar: PBPK modeling

Transporter Assays

Available Drug Transporter Assays and Test Systems
(Transporters in bold-face type include those listed in the FDA and EMA Guidance Documents and the ITC White Paper.)
  Cell Lines* Vesicles Double-transfected Oocytes Hepatocytes Animal Models
BCRP Monolayer X OATP1B1      
BSEP   X        
HTP1 X          
MATE1 X          
MATE2-K X          
MDR1 Monolayer X        

MRP1

   X        
MRP2   X OATP1B1      
MRP3   X        
MRP4   X        
MRP5   X        
NPT1 X          
NTCP1 X     X X  
NTCP2 X          
OAT1 X          
OAT2 X          
OAT3 X     X    
OAT4 X     X    
OAT7 X          
OATP1A2       X    
OATP1B1 X   MRP2 / BCRP X X  
OATP1B3 X     X X  
OATP2B1 X     X X  
OCT1 X     X    
OCT2 X     X    
OCT3 X          
OCTN1 X          
OCTN2 X          
PEPT1 X     X    
PEPT2 X     X    
URAT1 X          
dog Mdr1 X          
monkey Mdr1 X          
mouse Bcrp1 Monolayer     X   QWBA
mouse Bsep   X        
mouse Mdr1           QWBA
rat Bcrp           RBE
rat Bsep           RBE
rat Mdr1a RBEC monolayer         RBEC, RBMD
rat Mdr1b   X       QWBA
rat Mrp2   X       RBE, QWBA
rat Ntcp X          
rat Oat1a1 X         QWBA
rat Urat1 X          

QWBA: quantitative whole body autoradiography in standard animal strains or knock-out mice
RBE: rat biliary excretion
RBEC: rat brain endothelial cell
RBMD: rat brain microdialysis

*Transporters are expressed in: CHP, S2, HEK, S9, MDCK, MDCKII, Caco-2 and LLC-PK1 cell lines.  Some licenses are available, please contact us for details.