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Date Event Name
May 23, 2012 Webinar: PBPK modeling

Analytical Sciences

 

XenoTech’s Analytical Sciences department specializes in high quality support for all the analytical needs of our contract services groups.  Department personnel have a high level of expertise, pharma and CRO experience with thorough knowledge of the FDA and EMA Bioanalytical Guidelines.  The group's focus is on applying our LC/MS technology to maximize both the quality and throughput of the data we generate to ensure that your project needs are met.

Featured instruments and services include:

  • Multiple AB Sciex API2000, API3000, API4000 and API 5500 MS/MS systems
  • Waters Synapt™ G2 high-definition mass spectrometry system 
  • Multiple Shimadzu SIL-30AC, SIL-20AC, SIL-HT autosamplers minimize carryover and maximize throughput
  • Shimadzu Nexera UHPLC, UFLC and Prominence pumping systems
  • IN/US b-RAM radiometric detectors 
  • AIM Research LC-ARC detector provides enhanced sensitivity of radioactive compounds
  • Metabolite assays validated according to FDA Bioanalytical Guidelines
  • LC-UV

AB Sciex mass spectrometers
2 API 2000
3 API 3000
3 API 4000 QTRAP
2 API 5500 QTRAP

2 Waters Acquity UPLC systems

Shimadzu LC systems
4 Nexera UHPLC systems
4 Prominence UFLC systems
3 SIL-HT systems

Validated analytical methods - human liver microsomes

CYP Substrate Metabolite Monitored
CYP1A2 Phenacetin Acetaminophen
CYP2A6 Coumarin 7-Hydroxycoumarin
CYP2B6 Bupropion Hydroxybupropion
CYP2B6 Efavirenz 8-Hydroxyefavirenz
CYP2C8 Paclitaxel 6α-Hydroxypaclitaxel
CYP2C8 Amodiaquine N-Desethylamodiaquine
CYP2C9 Diclofenac 4´-Hydroxydiclofenac
CYP2C19 S-Mephenytoin 4´-Hydroxymephenytoin
CYP2D6 Dextromethorphan Dextrorphan
CYP2D6 Bufuralol 1´-Hydroxybufuralol
CYP2E1 Chlorzoxazone 6-Hydroxychlorzoxazone
CYP3A4/5 Testosterone 6β-Hydroxytestosterone
CYP3A4/5 Midazolam 1´-Hydroxymidazolam
CYP3A4/5 Nifedipine Dehydronifedipine
CYP3A4/5 Atorvastatin o-Hydroxyatorvastatin
CYP4A11 Lauric acid 12-Hydroxylauric acid
UGT1A1 Estradiol Estradiol-3-Glucuronide
UGT1A4 Trifluoperazine Trifluoperazine Glucuronide
UGT1A6 Naphthol 1-Naphthol Glucuronide
UGT1A6 4-Methylumbelliferone 4-Methylumbelliferone-β-D-Glucuronide
UGT1A9 Propofol Propofol Glucuronide
UGT2B7 Morphine Morphine 3-β-D-Glucuronide
UGT2B8 4-Methylumbelliferone 4-Methylumbelliferone-β-D-Glucuronide
NAT1 5-Aminosalicylic acid 5-Acetamido-salicylic acid
MAO-A 5-Hydroxytryptamine 5-Hydroxytryptophol
MAO-B 4-(Dimethyl amino)benzaldehyde 4-(Dimethyl amino)benzoic acid

Validated analytical methods - rat, mouse and monkey microsomes

CYP Species Metabolite Monitored
CYP2C11 Rat 2α-Hydroxytestosterone
CYP3A1/2 Rat 6β-Hydroxytestosterone
CYP2A1 Rat 7α-Hydroxytestosterone
CYP2B1/2 Rat 16β-Hydroxytestosterone
CYP2A4 Mouse 15α-Hydroxytestosterone
CYP2B10 Mouse 16β-Hydroxytestosterone
CYP3A11/13 Mouse 6β-Hydroxytestosterone
CYP2B17 Monkey 16α-Hydroxytestosterone
CYP2B17 Monkey 16β-Hydroxytestosterone
CYP3A8 Monkey 2β-Hydroxytestosterone
CYP3A8 Monkey 6β-Hydroxytestosterone

 

  • Deuterated internal standards ensure reliable results
  • Integrated electronic data transfer eliminates possible transcription errors