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Calendar of Events
| Date | Event Name |
|---|---|
| May 23, 2012 | Webinar: PBPK modeling |
Analytical Sciences
XenoTech’s Analytical Sciences department specializes in high quality support for all the analytical needs of our contract services groups. Department personnel have a high level of expertise, pharma and CRO experience with thorough knowledge of the FDA and EMA Bioanalytical Guidelines. The group's focus is on applying our LC/MS technology to maximize both the quality and throughput of the data we generate to ensure that your project needs are met.
Featured instruments and services include:
- Multiple AB Sciex API2000, API3000, API4000 and API 5500 MS/MS systems
- Waters Synapt™ G2 high-definition mass spectrometry system
- Multiple Shimadzu SIL-30AC, SIL-20AC, SIL-HT autosamplers minimize carryover and maximize throughput
- Shimadzu Nexera UHPLC, UFLC and Prominence pumping systems
- IN/US b-RAM radiometric detectors
- AIM Research LC-ARC detector provides enhanced sensitivity of radioactive compounds
- Metabolite assays validated according to FDA Bioanalytical Guidelines
- LC-UV
AB Sciex mass spectrometers
2 API 2000
3 API 3000
3 API 4000 QTRAP
2 API 5500 QTRAP
2 Waters Acquity UPLC systems
Shimadzu LC systems
4 Nexera UHPLC systems
4 Prominence UFLC systems
3 SIL-HT systems
Validated analytical methods - human liver microsomes
| CYP | Substrate | Metabolite Monitored |
| CYP1A2 | Phenacetin | Acetaminophen |
| CYP2A6 | Coumarin | 7-Hydroxycoumarin |
| CYP2B6 | Bupropion | Hydroxybupropion |
| CYP2B6 | Efavirenz | 8-Hydroxyefavirenz |
| CYP2C8 | Paclitaxel | 6α-Hydroxypaclitaxel |
| CYP2C8 | Amodiaquine | N-Desethylamodiaquine |
| CYP2C9 | Diclofenac | 4´-Hydroxydiclofenac |
| CYP2C19 | S-Mephenytoin | 4´-Hydroxymephenytoin |
| CYP2D6 | Dextromethorphan | Dextrorphan |
| CYP2D6 | Bufuralol | 1´-Hydroxybufuralol |
| CYP2E1 | Chlorzoxazone | 6-Hydroxychlorzoxazone |
| CYP3A4/5 | Testosterone | 6β-Hydroxytestosterone |
| CYP3A4/5 | Midazolam | 1´-Hydroxymidazolam |
| CYP3A4/5 | Nifedipine | Dehydronifedipine |
| CYP3A4/5 | Atorvastatin | o-Hydroxyatorvastatin |
| CYP4A11 | Lauric acid | 12-Hydroxylauric acid |
| UGT1A1 | Estradiol | Estradiol-3-Glucuronide |
| UGT1A4 | Trifluoperazine | Trifluoperazine Glucuronide |
| UGT1A6 | Naphthol | 1-Naphthol Glucuronide |
| UGT1A6 | 4-Methylumbelliferone | 4-Methylumbelliferone-β-D-Glucuronide |
| UGT1A9 | Propofol | Propofol Glucuronide |
| UGT2B7 | Morphine | Morphine 3-β-D-Glucuronide |
| UGT2B8 | 4-Methylumbelliferone | 4-Methylumbelliferone-β-D-Glucuronide |
| NAT1 | 5-Aminosalicylic acid | 5-Acetamido-salicylic acid |
| MAO-A | 5-Hydroxytryptamine | 5-Hydroxytryptophol |
| MAO-B | 4-(Dimethyl amino)benzaldehyde | 4-(Dimethyl amino)benzoic acid |
Validated analytical methods - rat, mouse and monkey microsomes
| CYP | Species | Metabolite Monitored |
| CYP2C11 | Rat | 2α-Hydroxytestosterone |
| CYP3A1/2 | Rat | 6β-Hydroxytestosterone |
| CYP2A1 | Rat | 7α-Hydroxytestosterone |
| CYP2B1/2 | Rat | 16β-Hydroxytestosterone |
| CYP2A4 | Mouse | 15α-Hydroxytestosterone |
| CYP2B10 | Mouse | 16β-Hydroxytestosterone |
| CYP3A11/13 | Mouse | 6β-Hydroxytestosterone |
| CYP2B17 | Monkey | 16α-Hydroxytestosterone |
| CYP2B17 | Monkey | 16β-Hydroxytestosterone |
| CYP3A8 | Monkey | 2β-Hydroxytestosterone |
| CYP3A8 | Monkey | 6β-Hydroxytestosterone |
- Deuterated internal standards ensure reliable results
- Integrated electronic data transfer eliminates possible transcription errors

