Single-Donor Human Hepatocytes

Single-donor cryopreserved human hepatocytes for suspension are a preferred test system for phase I and II in vitro drug metabolism studies. XenoTech’s human hepatocytes for suspension come in three different assured minimum yield (AMY) categories, allowing us to customize your order to meet the specific needs of your study.

Similar to our cryoplateable human hepatocytes, donors can be selected based on enzyme activity, demographics and any other characteristics. Uptake transporter characterization is also available for select lots.

If your study requires hepatocytes not included in our standard product offering, contact one of our product specialists to find out how XenoTech’s Custom Products can meet your needs.

Characterization Provided


Enzyme Marker Substrate Reaction
CYP1A2 Phenacetin O-dealkylation
CYP2A6 Coumarin 7-hydroxylation
CYP2B6 Bupropion hydroxylation
CYP2C8 Amodiaquine N-dealkylation
CYP2C9 Diclofenac 4'-hydroxylation
CYP2C19 S-Mephenytoin 4'-hydroxylation
CYP2D6 Dextromethorphan O-demethylation
CYP2E1 Chlorzoxazone 6-hydroxylation
CYP3A4/5 Testosterone 6β-hydroxylation
CYP3A4/5 Midazolam 1'-hydroxylation
 UGT 7-Hydroxycoumarin glucuronidation
SULT 7-Hydroxycoumarin sulfonation
OCT1* 1-Methyl-4-phenylpyridinium iodine
OATP1B1* Estrone-3-sulfate
OATP1B3* Cholecystokinin-8
NTCP* Taurocholic acid

*Uptake transporter characterization available on specified lots


Features and Benefits

  • Fully characterized using validated LC/MS/MS methods
  • Various AMY categories for easier product selection
  • Individual donor selection

View available lots and characterization information here.

View XenoTech's cryopreserved hepaotycte thawing protocol here.

Product Description Amount AMY
H1000.H15-3 Cryopreserved Human Hepatocytes for Suspension: Male Donor 1.5 mL 3M cells
H1000.H15B Cryopreserved Human Hepatocytes for Suspension: Male Donor 1.5 mL 4M cells
H1000.H15C Cryopreserved Human Hepatocytes for Suspension: Male Donor 1.5 mL 6M cells
H1000.H15T Uptake Transporter Characterized Human Hepatocytes: Male Donor 1.5 mL 4-6M cells
H1500.H15-3 Cryopreserved Human Hepatocytes for Suspension: Female Donor 1.5 mL 3M cells
H1500.H15B Cryopreserved Human Hepatocytes for Suspension: Female Donor 1.5 mL 4M cells
H1500.H15C Cryopreserved Human Hepatocytes for Suspension: Female Donor 1.5 mL 6M cells
H1500.H15T Uptake Transporter Characterized Human Hepatocytes: Male Donor 1.5 mL 4-6M cells


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