Treated Animal Liver Subcellular Fractions

Treating animals with various xenobiotics causes marked induction of liver microsomal CYP levels, which, in long term studies, may be associated with liver or thyroid tumor formation. XenoTech provides subcellular fractions from dogs and rats treated with prototypical inducers to serve as positive controls for ex vivo enzyme induction studies.

These products are pooled from many animals to ensure good representation of the inducer and to provide sufficient product availability. The following product information is included with each order of treated animal subcellular fractions.

Lot-Specific Information
Cytochrome P450 content
Cytochrome b5 content
NADPH-cytochrome c reductase activity
Activity of the inducible CYP enzyme
Dosing regimen
Animal husbandry conditions

If your study requires treated subcellular fractions not included in our standard product offering, contact one of our product specialists to find out how XenoTech’s Custom Products can meet your needs.

Product Description Amount Induced CYP
D1063 Microsomes from Clofibric acid-treated Beagle Dogs: male donor 0.5 mL at 20 mg/mL CYP4A
D1073 Microsomes from Saline-treated Beagle Dogs: male donor 0.5 mL at 20 mg/mL Vehicle Control
D1078 Microsomes from Phenobarbital- treated Beagle Dogs: male donor 0.5 mL at 20 mg/mL CYP2B
D1083 Microsomes from b-Naphthoflavone-treated Beagle Dogs: male donor 0.5 mL at 20 mg/mL CYP1A
D1095 Microsomes from Rifampin-treated Beagle Dogs: male donor 0.5 mL at 20 mg/mL CYP3A
D1098 Microsomes from Corn oil-treated Beagle Dogs: male donor 0.5 mL at 20 mg/mL Vehicle Control
P2073 Microsomes from Saline-treated Cynomolgus monkey: male donor 0.5 ml at 10 mg/mL None
P2078 Liver microsomes from Phenobarbital-treated Cynomolgus monkey: male donor 0.5 mL at 10 mg/mL CYP2A and CYP2B
P2083 Microsomes from BNF-treated Cynomolgus monkey: male donor 0.5 ml at 10 mg/mL CYP1A
P2085 Liver microsomes from Pyrazole-treated Cynomolgus monkey: Male Donor 0.5 mL at 10 mg/mL CYP2E
P2095 Microsomes from Rifampin-treated Cynomolgus monkey:male donor 0.5 ml at 10 mg/mL CYP3A
P2096 Liver microsomes from Omeprazole-treated Cynomolgus monkey: male donor 0.5 mL at 10 mg/mL CYP1A
P2573 Microsomes from Saline-treated Cynomolgus monkey: female donor 0.5 ml at 10 mg/mL None
P2578 Liver microsomes from Phenobarbital-treated Cynomolgus monkey: female donor 0.5 mL at 10 mg/mL CYP2A and CYP2B
P2583 Microsomes from BNF-treated Cynomolgus monkey: female donor 0.5 ml at 10 mg/mL CYP1A
P2585 Liver microsomes from Pyrazole-treated Cynomolgus monkey: female donor 0.5 mL at 10 mg/mL CYP2E
P2595 Microsomes from Rifampin-treated Cynomolgus monkey: female donor 0.5 ml at 10 mg/mL CYP3A
P2596 Liver microsomes from Omeprazole-treated Cynomolgus monkey: female donor 0.5 mL at 10 mg/mL CYP1A
R1063 Microsomes from Clofibric acid-treated Sprague-Dawley Rats: male donor 0.5 ml at 20 mg/mL CYP4A
R1073 Microsomes from Saline-treated Sprague-Dawley Rats: male donor 0.5 mL at 20 mg/mL Vehicle Control
R1078 Microsomes from Clofibric acid-treated Sprague-Dawley Rats: male donor 0.5 ml at 20 mg/mL CYP2B
R1081 Microsomes from b-Naphthoflavone and Phenobarbital-treated Sprague-Dawley Rats: male donor 0.5 mL at 20 mg/mL CYP1A and CYP2B
R1081.S9 S9 from b-Naphthoflavone and Phenobarbital-treated Sprague-Dawley Rats: male donor 0.5 ml at 20 mg/mL CYP1A and CYP2B
R1083 Microsomes from b-Naphthoflavone-treated Sprague-Dawley Rats: male donor 0.5 mL at 20 mg/mL CYP1A
R1088 Microsomes from Isoniazid-treated Sprague-Dawley Rats: male donor 0.5 ml at 20 mg/mL CYP2E
R1093 Microsomes from Dexamethasone-treated Sprague-Dawley Rats: male donor 0.5 mL at 20 mg/mL CYP3A
R1098 Microsomes from Corn Oil-treated Sprague-Dawley Rats: male donor 0.5 ml at 20 mg/mL Vehicle Control

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